Issue 19, 2007
From the journal:

Organic & Biomolecular Chemistry

Positional assignment of differentially substituted bisaminoacylated pdCpAs†

David J. Maloney,a   Noha Ghanem,a   Jia Zhoua  and  Sidney M. Hecht*a  

* Corresponding authors

a Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22904
E-mail: sidhecht@virginia.edu
Fax: +1 434/924-7856
Tel: +1 434/924-3906

Abstract

The synthesis and NMR analysis of a 2′-O-alanyl, 3′-O-[1-13C]valyl-pdCpA derivative has permitted the definitive assignment of the positions of acylation of tandemly activated pdCpAs, and the bisaminoacylated transfer RNAs derived therefrom.

Graphical abstract: Positional assignment of differentially substituted bisaminoacylated pdCpAs

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Article information

DOI
https://doi.org/10.1039/B708786A
Article type
Paper
Submitted
11 Jun 2007
Accepted
23 Jul 2007
First published
15 Aug 2007

Org. Biomol. Chem., 2007,5, 3135-3138

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Positional assignment of differentially substituted bisaminoacylated pdCpAs

D. J. Maloney, N. Ghanem, J. Zhou and S. M. Hecht, Org. Biomol. Chem., 2007, 5, 3135 DOI: 10.1039/B708786A

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