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Issue 16, 2007
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The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes

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Abstract

A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity–selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA.

Graphical abstract: The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes

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Supplementary files

Article information


Submitted
07 Jun 2007
Accepted
25 Jun 2007
First published
05 Jul 2007

Org. Biomol. Chem., 2007,5, 2555-2559
Article type
Communication

The importance of metal geometry in the recognition of G-quadruplex-DNA by metal-terpyridine complexes

H. Bertrand, D. Monchaud, A. De Cian, R. Guillot, J. Mergny and M. Teulade-Fichou, Org. Biomol. Chem., 2007, 5, 2555 DOI: 10.1039/B708635K

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