Issue 15, 2007
From the journal:

Organic & Biomolecular Chemistry

Total synthesis of luotonin A and 14-substituted analogues†

Jeffrey J. Masona  and  Jan Bergman*a  

* Corresponding authors

a Unit for Organic Chemistry, Department of Biosciences and Nutrition, Karolinska Institute, SE-14157, Huddinge, Sweden
E-mail: jabe@biosci.ki.se
Fax: +46 8-608-1501
Tel: +46 8-608-9204

Abstract

A new and concise synthesis of luotonin A was achieved from the previously described compounds ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate and 1-(2-nitrophenyl)prop-2-en-1-one. New 14-substituted luotonin A analogues were prepared using 14-chloroluotonin A as the key intermediate.

Graphical abstract: Total synthesis of luotonin A and 14-substituted analogues

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Article information

DOI
https://doi.org/10.1039/B707684C
Article type
Paper
Submitted
22 May 2007
Accepted
12 Jun 2007
First published
29 Jun 2007

Org. Biomol. Chem., 2007,5, 2486-2490

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Total synthesis of luotonin A and 14-substituted analogues

J. J. Mason and J. Bergman, Org. Biomol. Chem., 2007, 5, 2486 DOI: 10.1039/B707684C

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