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Issue 11, 2007
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Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol

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Abstract

Herein we report the first biochemical characterization of an enzyme involved in the biosynthesis of chloramphenicol that provides new insights into the origins of the antibiotic.

Graphical abstract: Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol

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Publication details

The article was received on 05 Mar 2007, accepted on 16 Apr 2007 and first published on 26 Apr 2007


Article type: Communication
DOI: 10.1039/B703356G
Org. Biomol. Chem., 2007,5, 1692-1694

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    Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol

    M. Pacholec, J. K. Sello, C. T. Walsh and M. G. Thomas, Org. Biomol. Chem., 2007, 5, 1692
    DOI: 10.1039/B703356G

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