Issue 10, 2007
From the journal:

Organic & Biomolecular Chemistry

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

Christopher D. Smith,a   Ian R. Baxendale,a   Geoffrey K. Tranmer,a   Marcus Baumann,a   Stephen C. Smith,b   Russell A. Lewthwaitec  and  Steven V. Ley*a  

* Corresponding authors

a Innovative Technology Centre (ACS), Department of Chemistry, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk
Fax: +44 (0)1223 336442
Tel: +44 (0)1223 336398

b Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, UK

c Pfizer Global Research and Development, Sandwich, Kent, UK

Abstract

The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.

Graphical abstract: Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

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Article information

DOI
https://doi.org/10.1039/B703033A
Article type
Paper
Submitted
28 Feb 2007
Accepted
19 Mar 2007
First published
16 Apr 2007

Org. Biomol. Chem., 2007,5, 1562-1568

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Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

C. D. Smith, I. R. Baxendale, G. K. Tranmer, M. Baumann, S. C. Smith, R. A. Lewthwaite and S. V. Ley, Org. Biomol. Chem., 2007, 5, 1562 DOI: 10.1039/B703033A

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