Issue 1, 2007

Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates

Abstract

DNA damage is a double-edged sword. The modifications produced in the biopolymer are associated with aging, and give rise to a variety of diseases, including cancer. DNA is also the target of anti-tumor agents and the most generally used nonsurgical treatment of cancer, ionizing radiation. Agents that damage DNA produce a variety of radicals. Elucidating the chemistry of individual DNA radicals is challenging due to the availability of multiple reactive pathways and complexities inherent with carrying out mechanistic studies on a heterogeneous polymer. The ability to independently generate radicals and their metastable products at defined sites in DNA has greatly facilitated understanding this biologically important chemistry.

Graphical abstract: Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates

Article information

Article type
Perspective
Submitted
04 Sep 2006
First published
14 Nov 2006

Org. Biomol. Chem., 2007,5, 18-30

Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates

M. M. Greenberg, Org. Biomol. Chem., 2007, 5, 18 DOI: 10.1039/B612729K

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