C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors

Vanessa Faugeroux; Yves Génisson; Nathalie Andrieu-Abadie; Sandra Colié; Thierry Levade; Michel Baltas

doi:10.1039/B613460B

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C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors

Vanessa Faugeroux,^a Yves Génisson,*^a Nathalie Andrieu-Abadie,^b Sandra Colié,^b Thierry Levade^b and Michel Baltas^a

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* Corresponding authors

^a Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, UMR 5068CNRS/Université Paul Sabatier, 118 route de Narbonne, Toulouse Cedex 9, France
E-mail: genisson@chimie.ups-tlse.fr
Fax: (+33) (0)5 61 55 82 45

^b Institut Louis Bugnard/INSERM U.466 CHU Rangueil, BP 84225, Toulouse Cedex 4, France

Abstract

The stereoselective preparation of novel C-alkyl 5-membered ring imino sugars and their biological evaluation with regard to GCS inhibition and cytotoxicity in a murine melanoma model are reported.

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Article information

DOI: https://doi.org/10.1039/B613460B
Article type: Communication
Submitted: 15 Sep 2006
Accepted: 19 Oct 2006
First published: 02 Nov 2006

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Org. Biomol. Chem., 2006,4, 4437-4439

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C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors

V. Faugeroux, Y. Génisson, N. Andrieu-Abadie, S. Colié, T. Levade and M. Baltas, Org. Biomol. Chem., 2006, 4, 4437 DOI: 10.1039/B613460B

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Organic & Biomolecular Chemistry

C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors

Abstract

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C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors

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