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Issue 24, 2006
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C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors

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Abstract

The stereoselective preparation of novel C-alkyl 5-membered ring imino sugars and their biological evaluation with regard to GCS inhibition and cytotoxicity in a murine melanoma model are reported.

Graphical abstract: C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors

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Publication details

The article was received on 15 Sep 2006, accepted on 19 Oct 2006 and first published on 02 Nov 2006


Article type: Communication
DOI: 10.1039/B613460B
Org. Biomol. Chem., 2006,4, 4437-4439

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    C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors

    V. Faugeroux, Y. Génisson, N. Andrieu-Abadie, S. Colié, T. Levade and M. Baltas, Org. Biomol. Chem., 2006, 4, 4437
    DOI: 10.1039/B613460B

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