Issue 22, 2006
From the journal:

Organic & Biomolecular Chemistry

A highly efficient and general method for the ring-opening of aziridines with various nucleophiles in DMSO

Jie Wu,*ab   Xiaoyu Suna  and  Wei Suna  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, China
E-mail: jie_wu@fudan.edu.cn
Fax: +86 21 6510 2412
Tel: +86 21 5566 4619

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, China

Abstract

Ring-opening of aziridines with various nucleophiles (such as amines, thiols, and silylated nucleophiles) in DMSO under mild conditions without any catalyst afforded the corresponding products in good to excellent yields.

Graphical abstract: A highly efficient and general method for the ring-opening of aziridines with various nucleophiles in DMSO

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Article information

DOI
https://doi.org/10.1039/B611707D
Article type
Paper
Submitted
14 Aug 2006
Accepted
21 Sep 2006
First published
13 Oct 2006

Org. Biomol. Chem., 2006,4, 4231-4235

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A highly efficient and general method for the ring-opening of aziridines with various nucleophiles in DMSO

J. Wu, X. Sun and W. Sun, Org. Biomol. Chem., 2006, 4, 4231 DOI: 10.1039/B611707D

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