Issue 22, 2006
From the journal:

Organic & Biomolecular Chemistry

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading

Bo Xu,a   Henry Pelish,b   Tomas Kirchhausenb  and  Gerald B. Hammond*a  

* Corresponding authors

a Department of Chemistry, University of Louisville, Louisville, Kentucky, USA

b CBR Institute for Biomedical Research and Department of Cell Biology, Harvard Medical School, 200 Longwood Ave., Boston, Massachusetts, USA

Abstract

We describe a large scale synthesis of secramine A. Consistent with its ability to inhibit activation of the small GTPase Cdc42, we find that secramine A inhibits cell spreading, a process previously shown to be Cdc42-dependent.

Graphical abstract: Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading

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Article information

DOI
https://doi.org/10.1039/B609143A
Article type
Paper
Submitted
27 Jun 2006
Accepted
25 Sep 2006
First published
05 Oct 2006

Org. Biomol. Chem., 2006,4, 4149-4157

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Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading

B. Xu, H. Pelish, T. Kirchhausen and G. B. Hammond, Org. Biomol. Chem., 2006, 4, 4149 DOI: 10.1039/B609143A

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