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Issue 18, 2006
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DNA nanomachines and nanostructures involving quadruplexes

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DNA is an attractive component for molecular recognition, because of its self-assembly properties. Its three-dimensional structure can differ markedly from the classical double helix. For example, DNA or RNA strands carrying guanine or cytosine stretches associate into four-stranded structures called G-quadruplexes or i-DNA, respectively. Since 2002, several groups have described nanomachines that take advantage of this structural polymorphism. We first introduce the unusual structures that are involved in these devices (i.e., i-DNA and G-quadruplexes) and then describe the opening and closing steps that allow cycling. A quadruplex–duplex molecular machine is then presented in detail, together with the rules that govern its formation, its opening/closing kinetics and the various technical and physico-chemical parameters that play a role in the efficiency of this device. Finally, we review the few examples of nanostructures that involve quadruplexes.

Graphical abstract: DNA nanomachines and nanostructures involving quadruplexes

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Publication details

The article was received on 21 Apr 2006 and first published on 22 Jun 2006

Article type: Perspective
DOI: 10.1039/B605739J
Citation: Org. Biomol. Chem., 2006,4, 3383-3391
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    DNA nanomachines and nanostructures involving quadruplexes

    P. Alberti, A. Bourdoncle, B. Saccà, L. Lacroix and J. Mergny, Org. Biomol. Chem., 2006, 4, 3383
    DOI: 10.1039/B605739J

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