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Issue 12, 2006
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Synthesis of spiro-pyridopyridine analogues by Grubbs' catalyst mediated alkene and enyne metathesis reaction

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Abstract

A practical synthesis of spiro-naphthyridinone derivatives is described by the combination of the Claisen rearrangement and ring-closing metathesis/ring-closing enyne metathesis process. The RCM or RCEM proceeded smoothly in the presence of Grubbs' first generation catalyst at room temperature under a nitrogen atmosphere.

Graphical abstract: Synthesis of spiro-pyridopyridine analogues by Grubbs' catalyst mediated alkene and enyne metathesis reaction

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Article information


Submitted
01 Mar 2006
Accepted
19 Apr 2006
First published
10 May 2006

Org. Biomol. Chem., 2006,4, 2393-2398
Article type
Paper

Synthesis of spiro-pyridopyridine analogues by Grubbs' catalyst mediated alkene and enyne metathesis reaction

K. C. Majumdar, R. Islam, H. Rahaman and B. Roy, Org. Biomol. Chem., 2006, 4, 2393
DOI: 10.1039/B603125K

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