Issue 1, 2006
From the journal:

Organic & Biomolecular Chemistry

Highly efficient methods for the one-pot synthesis of β-substituted enones

William J. Kerr,*a   Colin M. Pearsona  and  Graeme J. Thurstona  

* Corresponding authors

a WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, UK
E-mail: w.kerr@strath.ac.uk
Fax: +44 141 548 4246
Tel: +44 141 548 2959

Abstract

A mild and practically-convenient one-pot procedure for the direct β-substitution of enones has been developed using a conjugate addition–oxidation strategy with a full range of copper-based reagents and N-tert-butylphenylsulfinimidoyl chloride; alkyl- and aryl-substituted enones are delivered in good to excellent yields.

Graphical abstract: Highly efficient methods for the one-pot synthesis of β-substituted enones

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Article information

DOI
https://doi.org/10.1039/B512177A
Article type
Communication
Submitted
30 Aug 2005
Accepted
03 Nov 2005
First published
25 Nov 2005

Org. Biomol. Chem., 2006,4, 47-50

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Highly efficient methods for the one-pot synthesis of β-substituted enones

W. J. Kerr, C. M. Pearson and G. J. Thurston, Org. Biomol. Chem., 2006, 4, 47 DOI: 10.1039/B512177A

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