Issue 20, 2005

Micellar aggregates and hydrogels from phosphonobile salts

Abstract

The aggregation properties of novel bile acid analogs—phosphonobile salts (PBS)—have been studied. The critical micellar concentration of 23 and 24-phosphonobile salts were measured using fluorescence and 31P NMR methods. All the ten synthesized phosphonobile salts formed gels at different pH ranges in water. The pH range at which individual PBSs could gelate water was narrow and influenced by the number and conformation of hydroxyl groups. A reversible thermochromic system has been developed (with 23-phosphonodeoxycholate at pH 3.3), which changes color upon gelation. The investigation of the first hydrogels derived from trihydroxy bile acid analogs 1 and 6 was made using fluorescence, 31P NMR, X-ray crystallography, circular dichroism and SEM. The present studies reveal that the gel network consists of a chiral, fibrous structure possessing hydrophobic interiors.

Graphical abstract: Micellar aggregates and hydrogels from phosphonobile salts

Supplementary files

Article information

Article type
Paper
Submitted
04 Apr 2005
Accepted
03 Aug 2005
First published
08 Sep 2005

Org. Biomol. Chem., 2005,3, 3695-3700

Micellar aggregates and hydrogels from phosphonobile salts

P. Babu, D. Chopra, T. N. G. Row and U. Maitra, Org. Biomol. Chem., 2005, 3, 3695 DOI: 10.1039/B504656D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements