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Issue 13, 2005
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Near IR emitting isothiocyanato-substituted fluorophores: their synthesis and bioconjugation to monoclonal antibodies

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Abstract

Two near IR emitting fluorophores, based on the phthalocyanine and naphthalocyanine chromophores, which also bear a single isothiocyanato group suitable for conjugation to proteins are reported; their utility as luminescent probes is demonstrated by conjugation to monoclonal antibodies and the ability of these conjugates to selectively bind cells bearing the relevant antigen.

Graphical abstract: Near IR emitting isothiocyanato-substituted fluorophores: their synthesis and bioconjugation to monoclonal antibodies

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Publication details

The article was received on 25 Mar 2005, accepted on 13 May 2005 and first published on 31 May 2005


Article type: Communication
DOI: 10.1039/B504334D
Org. Biomol. Chem., 2005,3, 2384-2386

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    Near IR emitting isothiocyanato-substituted fluorophores: their synthesis and bioconjugation to monoclonal antibodies

    W. Duan, K. Smith, H. Savoie, J. Greenman and R. W. Boyle, Org. Biomol. Chem., 2005, 3, 2384
    DOI: 10.1039/B504334D

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