Issue 12, 2005
From the journal:

Organic & Biomolecular Chemistry

Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external β-turns

Heather M. E. Duggan,a   Peter B. Hitchcocka  and  Douglas W. Young*a  

* Corresponding authors

a Department of Chemistry, University of Sussex, Falmer, Brighton

Abstract

The 5/7-, 5/8- and 5/9-bicyclic lactams 3, 17, 5 and 6 have been synthesised as single diastereoisomers by a route involving ring closing olefin metathesis. The X-ray crystal structure of the amino acid hydrochloride 17 has been carried out and compared to that of the saturated external β-turn constraint 18.

Graphical abstract: Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external β-turns

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Article information

DOI
https://doi.org/10.1039/B503014E
Article type
Paper
Submitted
01 Mar 2005
Accepted
19 Apr 2005
First published
10 May 2005

Org. Biomol. Chem., 2005,3, 2287-2295

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Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external β-turns

H. M. E. Duggan, P. B. Hitchcock and D. W. Young, Org. Biomol. Chem., 2005, 3, 2287 DOI: 10.1039/B503014E

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