Exploiting the palladium[0]-catalysed Ullmann cross-coupling reaction in natural products chemistry: application to a total synthesis of the alkaloid (±)-aspidospermidine
Abstract
Azide 14, available through the title cross-coupling process, has been converted, via the ring-fused aziridine 15, into the alkaloid aspidospermidine.
- This article is part of the themed collection: Chemistry Nobel 2010 Web Collection: Cross-coupling reactions in organic chemistry