Issue 19, 2004
From the journal:

Organic & Biomolecular Chemistry

Effect of chain length on transfection properties of spermine-based gemini surfactants

Mariano Castro,a   Derek Griffiths,b   Alpesh Patel,a   Nicola Pattrick,b   Chris Kitson*b  and  Mark Ladlow*a  

* Corresponding authors

a GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: Mark.2.Ladlow@gsk.com

b GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK

Abstract

The synthesis and associated structure–activity relationships for gene transfection of a series of spermine-derived cationic gemini surfactants incorporating diamino acid headgroups and either identical (symmetrical) or different (unsymmetrical) lipophilic tailgroups is described. Transfection activity is found to depend critically upon the structural elements present.

Graphical abstract: Effect of chain length on transfection properties of spermine-based gemini surfactants

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Article information

DOI
https://doi.org/10.1039/B410240A
Article type
Paper
Submitted
06 Jul 2004
Accepted
17 Aug 2004
First published
10 Sep 2004

Org. Biomol. Chem., 2004,2, 2814-2820

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Effect of chain length on transfection properties of spermine-based gemini surfactants

M. Castro, D. Griffiths, A. Patel, N. Pattrick, C. Kitson and M. Ladlow, Org. Biomol. Chem., 2004, 2, 2814 DOI: 10.1039/B410240A

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