Issue 15, 2004
From the journal:

Organic & Biomolecular Chemistry

Synthesis and biological evaluation of caulibugulones A–E†

Peter Wipf,*a   Beomjun Joo,a   Theresa Nguyenb  and  John S. Lazob  

* Corresponding authors

a Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
E-mail: pwipf@pitt.edu
Fax: +1-412-624-0787
Tel: +1-412-624-8606

b Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA

Abstract

The marine bryozoan metabolites caulibugulone A–E were prepared from a readily available isoquinoline dione. These natural products were found to be potent and selective inhibitors of the dual specificity phosphatase Cdc25B.

Graphical abstract: Synthesis and biological evaluation of caulibugulones A–E

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Article information

DOI
https://doi.org/10.1039/B408184F
Article type
Communication
Submitted
01 Jun 2004
Accepted
18 Jun 2004
First published
05 Jul 2004

Org. Biomol. Chem., 2004,2, 2173-2174

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Synthesis and biological evaluation of caulibugulones A–E

P. Wipf, B. Joo, T. Nguyen and J. S. Lazo, Org. Biomol. Chem., 2004, 2, 2173 DOI: 10.1039/B408184F

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