Issue 7, 2004

A novel phase-switching protecting group for multi-step parallel solution phase synthesis

Abstract

A new phase-tag 1 which facilitates the parallel solution phase synthesis of carboxylic acids, esters, and carboxamides is reported. The new phase tag assists compound purification by enabling the selective resin capture of reaction products in either a reversible pH dependent manner (solid-phase extraction), or irreversibly in a Diels–Alder reaction.

Graphical abstract: A novel phase-switching protecting group for multi-step parallel solution phase synthesis

Article information

Article type
Paper
Submitted
07 Jan 2004
Accepted
28 Jan 2004
First published
25 Feb 2004

Org. Biomol. Chem., 2004,2, 989-998

A novel phase-switching protecting group for multi-step parallel solution phase synthesis

X. Li, C. Abell, M. S. Congreve, B. H. Warrington and M. Ladlow, Org. Biomol. Chem., 2004, 2, 989 DOI: 10.1039/B400110A

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