Issue 2, 2004

Microwave assisted Leimgruber–Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines

Abstract

The development of enhanced conditions for Lewis acid catalysed Leimgruber–Batcho indole synthesis using microwave acceleration is described. This approach has permitted the preparation of a variety of heteroaromatic enamine intermediates in good yield and high purities. Subsequent catalytic hydrogenation reactions, under various conditions including the use of a solid-phase encapsulated catalyst, furnish the corresponding indole derivatives in good yields.

Graphical abstract: Microwave assisted Leimgruber–Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines

Supplementary files

Article information

Article type
Paper
Submitted
17 Oct 2003
Accepted
19 Nov 2003
First published
16 Dec 2003

Org. Biomol. Chem., 2004,2, 160-167

Microwave assisted Leimgruber–Batcho reaction for the preparation of indoles, azaindoles and pyrroylquinolines

J. Siu, I. R. Baxendale and S. V. Ley, Org. Biomol. Chem., 2004, 2, 160 DOI: 10.1039/B313012F

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