Issue 1, 2004

A ‘molecular switchboard’—covalent modifications to proteins and their impact on transcription

Abstract

Proteins undergo a remarkable variety of posttranslational modifications, with more than 200 distinct modifications identified to date. Increasing evidence suggests that many proteins bear multiple, distinct modifications, and the ability of one modification to antagonize or synergize the deposition of another can have significant biological consequences. Here, we illustrate the importance of posttranslational modifications within the context of transcriptional regulation, and we offer a perspective on the emerging role of combinatorial networks of modifications. Finally, we discuss the potential for chemical approaches to transform our understanding of the field.

Graphical abstract: A ‘molecular switchboard’—covalent modifications to proteins and their impact on transcription

Supplementary files

Article information

Article type
Emerging Area
Submitted
07 Oct 2003
Accepted
11 Nov 2003
First published
02 Dec 2003

Org. Biomol. Chem., 2004,2, 1-7

A ‘molecular switchboard’—covalent modifications to proteins and their impact on transcription

N. Khidekel and L. C. Hsieh-Wilson, Org. Biomol. Chem., 2004, 2, 1 DOI: 10.1039/B312466E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements