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Issue 1, 2004
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Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with a 1-propynyl group

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Abstract

The Pd(0)-mediated rapid coupling (trapping) reaction of methyl iodide with an excess amount of alkynyltributylstannane has been developed with the aim to incorporate a short-lived 11C-labeled methyl group into biologically active organic compounds with a 1-propynyl structural unit.

Graphical abstract: Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with a 1-propynyl group

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Publication details

The article was received on 22 Sep 2003, accepted on 30 Oct 2003 and first published on 11 Nov 2003


Article type: Communication
DOI: 10.1039/B311532A
Org. Biomol. Chem., 2004,2, 24-27

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    Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with a 1-propynyl group

    T. Hosoya, M. Wakao, Y. Kondo, H. Doi and M. Suzuki, Org. Biomol. Chem., 2004, 2, 24
    DOI: 10.1039/B311532A

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