Direct synthesis of unprotected phenols using palladium-catalysed cross coupling reactions of functionalised organozinc reagents

Abstract

Palladium-catalysed reaction of unprotected 2-, 3-, and 4-iodophenols with a range of amino acid derived organozinc reagents (not used in excess) gives the expected products in good to excellent yield, demonstrating that carbon–zinc bonds are not protonated by acidic phenols under the conditions of palladium-catalysed coupling reactions.