Issue 21, 2003

Synthesis of unprotected and borane-protected cyclic phosphines using Ru– and Mo– based olefin metathesis catalysts

Abstract

Ru– and Mo-based catalysts can be used in ring closing metathesis (RCM) reactions to synthesise cyclic phosphines protected as their borane complexes. The compatibility of the Schrock Mo-catalyst and the N-heterocyclic carbene Ru-catalysts with this class of substrates is particularly noteworthy as asymmetric RCM (ARCM) is now emerging as a new tool for the preparation of homochiral phosphines. One of the key results is that the Mo-catalyst allows the ring closure of the unprotected diallylphenylphosphine with 95% conversion.

Graphical abstract: Synthesis of unprotected and borane-protected cyclic phosphines using Ru– and Mo– based olefin metathesis catalysts

Article information

Article type
Paper
Submitted
17 Jun 2003
Accepted
18 Aug 2003
First published
10 Sep 2003

Org. Biomol. Chem., 2003,1, 3820-3825

Synthesis of unprotected and borane-protected cyclic phosphines using Ru– and Mo– based olefin metathesis catalysts

C. A. Slinn, A. J. Redgrave, S. Lucy Hind, C. Edlin, S. P. Nolan and V. Gouverneur, Org. Biomol. Chem., 2003, 1, 3820 DOI: 10.1039/B306940K

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