Issue 14, 2003
From the journal:

Organic & Biomolecular Chemistry

Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors

Emma Vickerstaffe,a   Brian H. Warrington,a   Mark Ladlow*a  and  Steven V. Ley*b  

* Corresponding authors

a GlaxoSmithKline Cambridge Technology Centre, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: Mark.2.Ladlow@gsk.com
Fax: +44 (0) 1223 331532
Tel: +44 (0) 1223 336349

b Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk
Fax: +44 (0) 1223 336442
Tel: +44 (0) 1223 336398

Abstract

The first fully automated multi-step polymer assisted solution phase (PASP) synthesis is described. An array of histone deacetylase (HDAc) inhibitors was prepared by an unattended 4–5 step sequence incorporating in-line ‘catch and release’ purification.

Graphical abstract: Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors

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Article information

DOI
https://doi.org/10.1039/B305713E
Article type
Communication
Submitted
22 May 2003
Accepted
18 Jun 2003
First published
20 Jun 2003

Org. Biomol. Chem., 2003,1, 2419-2422

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Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors

E. Vickerstaffe, B. H. Warrington, M. Ladlow and S. V. Ley, Org. Biomol. Chem., 2003, 1, 2419 DOI: 10.1039/B305713E

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