Issue 32, 2020

Homogeneous nanodiscs of native membranes formed by stilbene–maleic-acid copolymers

Abstract

Methylstilbene-alt-maleic acid copolymers spontaneously convert biological membranes into bilayer discs with ∼20 nm diameters. This readily functionalizable class of copolymers has the compositional homogeneity, hydrophobicity, dynamics, and charge that may help to achieve optimal structural resolution, membrane dissolution, stability, and broad utility.

Graphical abstract: Homogeneous nanodiscs of native membranes formed by stilbene–maleic-acid copolymers

Supplementary files

Article information

Article type
Communication
Submitted
02 May 2020
Accepted
11 Jul 2020
First published
11 Aug 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2020,12, 16705-16709

Homogeneous nanodiscs of native membranes formed by stilbene–maleic-acid copolymers

M. Esmaili, C. J. Brown, R. Shaykhutdinov, C. Acevedo-Morantes, Y. L. Wang, H. Wille, R. D. Gandour, S. R. Turner and M. Overduin, Nanoscale, 2020, 12, 16705 DOI: 10.1039/D0NR03435E

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