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Issue 22, 2020
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Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications

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Abstract

As one of the promising orthopedic materials, polyetheretherketone (PEEK) has high chemical durability and similar mechanical properties to the cortical bone; nevertheless, the inherent bioinert nature of PEEK dramatically impedes its broader clinical applications in the management of bone infection. To address this challenge, herein, we developed a multifunctional two-dimensional (2D) nanocoating to assemble graphene oxide (GO) nanosheets, a polydopamine (pDA) nanofilm, and an oligopeptide onto the surface of porous sulfonated PEEK (SPEEK). The resulting multifunctional PEEK implants exhibited enhanced cytocompatibility, alkaline phosphatase activity, and calcium matrix deposition as well as osteogenesis-associated gene expression. Moreover, the animal experiments based on a rabbit femur defect model confirmed that the 2D nanocoating prominently boosted the in vivo osseointegration and bone remodeling. Besides, the GO/pDA hybrid complex anchoring on the SPEEK surface through π–π stacking can generate robust antibacterial phototherapy resulting from the synergetic photothermal/photodynamic therapeutic effects. Accordingly, this work provides a paradigm to empower inert PEEK implants with bi-/multi-modal therapeutic applications, such as against bone infection treatment.

Graphical abstract: Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications

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Submitted
23 Mar 2020
Accepted
11 May 2020
First published
12 May 2020

Nanoscale, 2020,12, 11936-11946
Article type
Paper

Two-dimensional nanocoating-enabled orthopedic implants for bimodal therapeutic applications

S. Wang, C. Duan, W. Yang, X. Gao, J. Shi, J. Kang, Y. Deng, X. Shi and Z. Chen, Nanoscale, 2020, 12, 11936
DOI: 10.1039/D0NR02327B

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