Issue 15, 2020

Ln3+-doped nanoparticles with enhanced NIR-II luminescence for lighting up blood vessels in mice

Abstract

Probes functioning in the second near-infrared window (1000–1700 nm, NIR-II) exhibit higher resolution and diminished auto-fluorescence compared to those in the traditional NIR region (700–950 nm). Here, we designed and synthesized rare earth ion doped probes with core/shell/shell structures and bright luminescence in the NIR-II region excited at 808 nm. With the doping of Ce3+ ions, the emission intensity of Er3+ at 1530 nm increased 10 times, while the upconversion luminescence decreased to less than 1%. After being modified with polyacrylic acid and polyethylene glycol, the as-obtained water-soluble probe exhibits continuous high-resolution for distinguishing 0.25 mm blood vessels even 10 h after injection. Noteworthily, the imaging of tumors was achieved by injecting the probe, indicating that the designed NIR-II probe has sufficient brightness and the ability to passively target tumor tissue.

Graphical abstract: Ln3+-doped nanoparticles with enhanced NIR-II luminescence for lighting up blood vessels in mice

Supplementary files

Article information

Article type
Paper
Submitted
08 Feb 2020
Accepted
07 Mar 2020
First published
13 Mar 2020

Nanoscale, 2020,12, 8248-8254

Ln3+-doped nanoparticles with enhanced NIR-II luminescence for lighting up blood vessels in mice

C. Cao, N. Wu, W. Yuan, Y. Gu, J. Ke, W. Feng and F. Li, Nanoscale, 2020, 12, 8248 DOI: 10.1039/D0NR01098G

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