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Issue 11, 2020

Autophagic stress; a new cellular response to nanoparticles. Could it be a new strategy for inhibition of liver cancer cell invasion and metastasis?

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Abstract

We herein report a new biological consequence from a unique interaction between nanoparticles of ferric–tannic complexes (Fe–TA NPs) and liver cancer cells (HepG2.2.15). The Fe–TA NPs were found to accumulate into the cells via specific cellular uptake mechanisms and thereafter disturbed cellular autophagy and cellular pH homeostasis, which led the cells to undergo autophagic stress and eventual death. According to biophysical analysis, the cells undergoing autophagic stress were found to lose their capability of attachment, migration, and movement. Similarly, KEGG analysis demonstrated the down-regulation of TGF-beta indicating that the autophagic stress is capable of reducing cancer cell invasion. Therefore, the Fe–TA NPs could be considered beneficial as a new pharmaceutical nanoplatform for liver cancer treatment via induction of autophagic stress.

Graphical abstract: Autophagic stress; a new cellular response to nanoparticles. Could it be a new strategy for inhibition of liver cancer cell invasion and metastasis?

Supplementary files

Article information


Submitted
29 Nov 2019
Accepted
13 Feb 2020
First published
18 Feb 2020

Nanoscale, 2020,12, 6556-6561
Article type
Paper

Autophagic stress; a new cellular response to nanoparticles. Could it be a new strategy for inhibition of liver cancer cell invasion and metastasis?

C. Pilapong, T. Phatruengdet and S. Krungchanuchat, Nanoscale, 2020, 12, 6556 DOI: 10.1039/C9NR10131D

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