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Issue 41, 2019
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Plasmonic bimetallic nanodisk arrays for DNA conformation sensing

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Abstract

The integration of large-scale 2D bimetallic Ag/Au nanodisk arrays with gold nanoparticles is developed for sensing DNA conformation with the assistance of 3D finite-difference time-domain simulation. The optimized system comprising Ag/Au nanodisk arrays and gold nanoparticles offers a more than 6-fold enhancement in surface plasmon resonance shift, enabling the feasibility for sensitive DNA detection with a detection limit down to 100 femtomolar. Importantly, owing to the distance-dependent nature of the surface plasmon signal, sensitive differentiation of DNA conformations can be achieved with a conventional optical measurement. This platform could provide new exciting capabilities for a reliable, reproducible, and label-free assay analysis for investigating the conformations of DNA and other biological molecules.

Graphical abstract: Plasmonic bimetallic nanodisk arrays for DNA conformation sensing

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Supplementary files

Article information


Submitted
18 Jul 2019
Accepted
08 Sep 2019
First published
09 Sep 2019

Nanoscale, 2019,11, 19291-19296
Article type
Communication

Plasmonic bimetallic nanodisk arrays for DNA conformation sensing

T. T. V. Nguyen, X. Xie, J. Xu, Y. Wu, M. Hong and X. Liu, Nanoscale, 2019, 11, 19291
DOI: 10.1039/C9NR06101K

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