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Issue 25, 2019
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The molecular basis of interaction domains of full-length PrP with lipid membranes

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Abstract

PrP–lipid membrane interactions are critical to PrP structural conversion and neurotoxicity, but its molecular mechanism remains unclear. A two-dimensional histogram of force–distance curves and a worm-like chain model revealed three binding regions at the PrP N-terminal, providing the molecular basis for understanding the interactions between full-length PrP and lipid membranes.

Graphical abstract: The molecular basis of interaction domains of full-length PrP with lipid membranes

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Publication details

The article was received on 29 Mar 2019, accepted on 02 Jun 2019 and first published on 04 Jun 2019


Article type: Communication
DOI: 10.1039/C9NR02735A
Nanoscale, 2019,11, 12087-12091

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    The molecular basis of interaction domains of full-length PrP with lipid membranes

    Y. Pan, B. Wang, R. A. Reese and B. Xu, Nanoscale, 2019, 11, 12087
    DOI: 10.1039/C9NR02735A

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