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Issue 20, 2019
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Gram-scale fabrication of Bi@C nanoparticles through one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy

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Abstract

At present, increasing attention is being paid to photothermal therapy corresponding to the second near infrared (NIR-II) range (1000–1700 nanometers); however, its biomedical applications related to carbon-based nanomaterials (CNMs) have always been limited by the large-scale fabrication of excellent diagnostic probes with a suitable size and optical absorption cross-section. Herein, we successfully prepared Bi@C nanoparticles with a suitable size and high output (3.14 g per patch) through a one-pot hydrothermal method. By combining Bi with carbon, the optical absorption in the NIR-II range was enhanced compared to that for single carbon; moreover, Bi@C could no longer be easily oxidized due to the protection of outer C compared with individual Bi. Furthermore, because of the high atomic number of Bi (Z = 83), the Bi@C nanoparticles exhibited computed imaging contrast properties. According to the in vitro and in vivo experiments, the Bi@C nanoparticles could ablate cancer cells under illumination with a 1064 nm laser with deeper penetration and an appropriate permissible exposure (MPE) to the laser (1 W cm−2), showing excellent performance for the diagnosis and treatment of tumors. This study provides a simple method to synthesize metal–carbon nanocomposites to enhance the NIR-II optical absorption efficiency for effective deep-seated tumor photothermal therapy and will further broaden the applications of CNMs.

Graphical abstract: Gram-scale fabrication of Bi@C nanoparticles through one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy

  • This article is part of the themed collection: Nanocarbons
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Publication details

The article was received on 20 Feb 2019, accepted on 30 Apr 2019 and first published on 01 May 2019


Article type: Paper
DOI: 10.1039/C9NR01557D
Nanoscale, 2019,11, 9906-9911

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    Gram-scale fabrication of Bi@C nanoparticles through one-step hydrothermal method for dual-model imaging-guided NIR-II photothermal therapy

    W. Zhen, S. An, W. Wang, Y. Liu, X. Jia, C. Wang, M. Zhang and X. Jiang, Nanoscale, 2019, 11, 9906
    DOI: 10.1039/C9NR01557D

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