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Issue 21, 2019
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Packaging of DNA origami in viral capsids

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Abstract

Here we show the encapsulation of 35 nm diameter, nearly-spherical, DNA origami by self-assembly of SV40-like (simian virus 40) particles. The self-assembly of this new type of nanoparticles is highly reproducible and efficient. The structure of these particles was determined by cryo-EM. The capsid forms a regular SV40 lattice of T = 7d icosahedral symmetry and the structural features of encapsulated DNA origami are fully visible. These particles are a promising biomaterial for use in various medical applications.

Graphical abstract: Packaging of DNA origami in viral capsids

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Article information


Submitted
14 Dec 2018
Accepted
11 Apr 2019
First published
17 Apr 2019

Nanoscale, 2019,11, 10160-10166
Article type
Communication

Packaging of DNA origami in viral capsids

I. Kopatz, R. Zalk, Y. Levi-Kalisman, E. Zlotkin-Rivkin, G. A. Frank and S. Kler, Nanoscale, 2019, 11, 10160
DOI: 10.1039/C8NR10113B

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