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Issue 14, 2019
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A new tool to attack biofilms: driving magnetic iron-oxide nanoparticles to disrupt the matrix

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Abstract

A main feature of biofilms is the self-produced extracellular polymeric substances (EPSs) that act as a protective shield, preventing biocide penetration. We use magnetic iron oxide nanoparticles (MNPs) in combination with magnetic fields to damage the biofilm matrix and cause detachment. A Methicillin-resistant Staphylococcus aureus (MRSA) biofilm strain is used to demonstrate the efficacy of the methodology with different sizes and concentrations of MNPs under AC and DC applied field conditions. We achieve up to a nearly 5 log10 reduction in biofilm bacteria after treatment with 30 mg mL−1 of 11 nm MNPs using a magnetic field. The MNPs cause significant mechanical disruption to the matrix and lead to biofilm dispersal. In addition, using magnetic hyperthermia further affects biofilm damage.

Graphical abstract: A new tool to attack biofilms: driving magnetic iron-oxide nanoparticles to disrupt the matrix

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Supplementary files

Article information


Submitted
04 Dec 2018
Accepted
19 Mar 2019
First published
19 Mar 2019

Nanoscale, 2019,11, 6905-6915
Article type
Paper

A new tool to attack biofilms: driving magnetic iron-oxide nanoparticles to disrupt the matrix

J. Li, R. Nickel, J. Wu, F. Lin, J. van Lierop and S. Liu, Nanoscale, 2019, 11, 6905
DOI: 10.1039/C8NR09802F

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