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Issue 4, 2019
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Surface-engineered vanadium nitride nanosheets for an imaging-guided photothermal/photodynamic platform of cancer treatment

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Abstract

Of the many strategies for precise tumor treatment, near-infrared (NIR) light-activated “one-for-all” theranostic modality with real-time diagnosis and therapy has attracted extensive attention from researchers. Herein, a brand-new theranostic nanoplatform was established on versatile vanadium nitride (VN) nanosheets, which show significant NIR optical absorption, and resultant photothermal effect and reactive oxygen species activity under NIR excitation, thereby realizing the synergistic action of photothermal/photodynamic co-therapy. As expected, systematic in vitro and in vivo antitumor evaluations demonstrated efficient cancer cell killing and solid tumor removal without recurrence. Meanwhile, the surface modification of VN nanosheets with poly(allylamine hydrochloride) and bovine serum albumin enhanced the biocompatibility of VN and made it more suitable for in vivo delivery. Moreover, VN has been ascertained as a potential photoacoustic imaging contrast for in vivo tumor depiction. Thus, this work highlights the potential of VN nanosheets as a single-component theranostic nanoplatform.

Graphical abstract: Surface-engineered vanadium nitride nanosheets for an imaging-guided photothermal/photodynamic platform of cancer treatment

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Publication details

The article was received on 21 Nov 2018, accepted on 22 Dec 2018 and first published on 27 Dec 2018


Article type: Paper
DOI: 10.1039/C8NR08269C
Citation: Nanoscale, 2019,11, 1968-1977

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    Surface-engineered vanadium nitride nanosheets for an imaging-guided photothermal/photodynamic platform of cancer treatment

    C. Yang, H. Yu, Y. Gao, W. Guo, Z. Li, Y. Chen, Q. Pan, M. Ren, X. Han and C. Guo, Nanoscale, 2019, 11, 1968
    DOI: 10.1039/C8NR08269C

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