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Issue 44, 2018
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The potential of magnetic hyperthermia for triggering the differentiation of cancer cells

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Abstract

Magnetic hyperthermia is a potential technique for cancer therapy that exploits heat generated by magnetic nanoparticles to kill cancerous cells. Many studies have shown that magnetic hyperthermia is effective at killing cancer cells both in vitro and in vivo, however little attention has been paid to the cellular functioning of the surviving cells. We report here new evidence demonstrating the onset of thermally triggered differentiation in osteosarcoma cancer cells that survive magnetic hyperthermia treatment. This raises the possibility that in addition to causing cell death, magnetic hyperthermia could induce surviving cancer cells to form more mature cell types and thereby inhibit their capacity to self-renew. Such processes could prove to be as important as cell death when considering magnetic hyperthermia for treating cancer.

Graphical abstract: The potential of magnetic hyperthermia for triggering the differentiation of cancer cells

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Article information


Submitted
23 Jul 2018
Accepted
28 Oct 2018
First published
29 Oct 2018

This article is Open Access

Nanoscale, 2018,10, 20519-20525
Article type
Communication

The potential of magnetic hyperthermia for triggering the differentiation of cancer cells

S. Moise, J. M. Byrne, A. J. El Haj and N. D. Telling, Nanoscale, 2018, 10, 20519
DOI: 10.1039/C8NR05946B

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