Jump to main content
Jump to site search

Issue 40, 2018
Previous Article Next Article

A biodegradable fluorescent nanohybrid for photo-driven tumor diagnosis and tumor growth inhibition

Author affiliations

Abstract

Specific targeting and phototriggered therapy in mouse model have recently emerged as the starting point of cancer theragnosis. Herein, we report a bioresponsive and degradable nanohybrid, a liposomal nanohybrid decorated with red emissive carbon dots, for localized tumor imaging and light-mediated tumor growth inhibition. Unsaturated carbon dots (C-dots) anchored to liposomes convert near-infrared (NIR) light into heat and also produce reactive oxygen species (ROS), demonstrating the capability of phototriggered cancer cell death and tumor regression. The photothermal and oxidative damage of breast tumor by the nonmetallic nanohybrid has also been demonstrated. Designed nanoparticles show excellent aqueous dispersibility, biocompatibility, light irradiated enhanced cellular uptake, release of reactive oxygen species, prolonged and specific tumor binding ability and good photothermal response (62 °C in 5 minutes). Safe and localized irradiation of 808 nm light demonstrates significant tumor growth inhibition and bioresponsive degradation of the fluorescent nanohybrid without affecting the surrounding healthy tissues.

Graphical abstract: A biodegradable fluorescent nanohybrid for photo-driven tumor diagnosis and tumor growth inhibition

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Jun 2018, accepted on 18 Sep 2018 and first published on 21 Sep 2018


Article type: Paper
DOI: 10.1039/C8NR05164J
Citation: Nanoscale, 2018,10, 19082-19091

  •   Request permissions

    A biodegradable fluorescent nanohybrid for photo-driven tumor diagnosis and tumor growth inhibition

    R. Prasad, D. S. Chauhan, A. S. Yadav, J. Devrukhkar, B. Singh, M. Gorain, M. Temgire, J. Bellare, G. C. Kundu and R. Srivastava, Nanoscale, 2018, 10, 19082
    DOI: 10.1039/C8NR05164J

Search articles by author

Spotlight

Advertisements