Issue 22, 2018

Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

Abstract

A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications.

Graphical abstract: Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

Supplementary files

Article information

Article type
Communication
Submitted
12 Mar 2018
Accepted
13 Apr 2018
First published
13 Apr 2018

Nanoscale, 2018,10, 10333-10336

Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor

Q. Huang, K. I. Kuok, X. Zhang, L. Yue, S. M. Y. Lee, J. Zhang and R. Wang, Nanoscale, 2018, 10, 10333 DOI: 10.1039/C8NR02041H

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