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Issue 19, 2018
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Deciphering the role of substrate stiffness in enhancing the internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers

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Abstract

This study investigates the role of substrate stiffness in the non-viral transfection of human adipose-derived stem cells (hASCs) with the aim to maximize the hASC expression of vascular endothelial growth factor (VEGF). The results confirm the direct effect of substrate stiffness in regulating cytoskeletal remodeling and corresponding plasmid internalization.

Graphical abstract: Deciphering the role of substrate stiffness in enhancing the internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers

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Article information


Submitted
22 Feb 2018
Accepted
05 Apr 2018
First published
06 Apr 2018

Nanoscale, 2018,10, 8947-8952
Article type
Communication

Deciphering the role of substrate stiffness in enhancing the internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers

S. Modaresi, S. Pacelli, J. Whitlow and A. Paul, Nanoscale, 2018, 10, 8947
DOI: 10.1039/C8NR01516C

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