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Issue 47, 2017
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A specific HeLa cell-labelled and lysosome-targeted upconversion fluorescent probe: PEG-modified Sr2YbF7:Tm3+

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Abstract

In this study, water-soluble PEG-modified Sr2YbF7:Tm3+ was prepared conveniently by a one-pot solvothermal method, where the molar ratio of Sr2+ to Yb3+ was controlled between 3 : 2 and 1 : 1. The optimum red-light emission at 677–699 nm was modulated via 0.7% Tm3+ doped under irradiation at 980 nm. Interestingly, biological experimental results showed that the PEG-modified Sr2YbF7:Tm3+ with low toxicity, excellent cell membrane permeability and high photostability can not only distinguish HeLa cells from mouse embryonic fibroblasts but also target the subcellular organelle lysosome in HeLa cells; therefore it can be anticipated that the as-prepared material would be a potential tool for cancer diagnosis.

Graphical abstract: A specific HeLa cell-labelled and lysosome-targeted upconversion fluorescent probe: PEG-modified Sr2YbF7:Tm3+

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Publication details

The article was received on 22 Sep 2017, accepted on 05 Nov 2017 and first published on 06 Nov 2017


Article type: Paper
DOI: 10.1039/C7NR07093D
Citation: Nanoscale, 2017,9, 18861-18866

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    A specific HeLa cell-labelled and lysosome-targeted upconversion fluorescent probe: PEG-modified Sr2YbF7:Tm3+

    L. Xiang, H. Zhang, H. Li, L. Kong, H. Zhou, J. Wu, Y. Tian, J. Zhang and Y. Mao, Nanoscale, 2017, 9, 18861
    DOI: 10.1039/C7NR07093D

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