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Issue 40, 2017
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Quantum capacitance as a reagentless molecular sensing element

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Abstract

The application of nanoscale capacitance as a transduction of molecular recognition relevant to molecular diagnostics is demonstrated. The energy-related signal relates directly to the electron occupation of quantized states present in readily fabricated molecular junctions such as those presented by redox switchable self-assembled molecular monolayers, reduced graphene oxide or redox-active graphene composite films, assembled on standard metallic or micro-fabricated electrodes. Sensor design is thus based on the response of a confined and resolved electronic density of states to target binding and the associated change in interfacial chemical potential. Demonstrated herein with a number of clinically important markers, this represents a new potent and ultrasensitive molecular detection enabling energy transducer principle capable of quantifying, in a single step and reagentless manner, markers within biological fluid.

Graphical abstract: Quantum capacitance as a reagentless molecular sensing element

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Supplementary files

Article information


Submitted
18 Aug 2017
Accepted
18 Sep 2017
First published
18 Sep 2017

Nanoscale, 2017,9, 15362-15370
Article type
Paper

Quantum capacitance as a reagentless molecular sensing element

P. R. Bueno, F. C. Bedatty Fernandes and J. J. Davis, Nanoscale, 2017, 9, 15362 DOI: 10.1039/C7NR06160A

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