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Issue 41, 2017
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Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading

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Abstract

Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL−1. The dual-loaded nanoparticles were effective in killing cancer cells, which has the potential to minimize the amount of nanocarriers needed for clinical applications, due to their ultrahigh loading capacity.

Graphical abstract: Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading

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Publication details

The article was received on 10 Aug 2017, accepted on 10 Oct 2017 and first published on 16 Oct 2017


Article type: Communication
DOI: 10.1039/C7NR05935C
Citation: Nanoscale, 2017,9, 15773-15777

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    Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading

    F. Zhang, S. Khan, R. Li, J. A. Smolen, S. Zhang, G. Zhu, L. Su, A. A. Jahnke, M. Elsabahy, X. Chen and K. L. Wooley, Nanoscale, 2017, 9, 15773
    DOI: 10.1039/C7NR05935C

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