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Issue 48, 2017
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Plasmon-mediated cancer phototherapy: the combined effect of thermal and photodynamic processes

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Abstract

A nanoplatform for simultaneous cellular imaging, and photodynamic and photothermal therapies has been designed and realized by embedding a purposely synthesized highly luminescent water soluble iridium(III) compound into gold core–silica shell nanoparticles. These multifunctionalities arise mainly from the photophysical properties of the cyclometalated complex: (i) the heavy atom promotes, through excited triplet state formation, energy transfer processes towards molecular oxygen, with the generation of 1O2 (photodynamic effect); (ii) the overlap of the iridium(III) complex emission band with the plasmonic resonance of gold nanostructures allows excitation energy transfer towards the metallic core (photothermal effect); (iii) the remarkable iridium(III) complex luminescence feature, which is preserved despite energy transfer processes, makes the whole system an efficient luminescent bio-probe (imaging). Photophysical and photothermal investigations have been carried out, whereas in vitro photo-cytotoxicity tests have been performed on human glioblastoma cells (U87MG), highlighting significant cancer cell death at a very low photosensitizer concentration (<0.5 μM), by means of a synergistic photodynamic and photothermal effect.

Graphical abstract: Plasmon-mediated cancer phototherapy: the combined effect of thermal and photodynamic processes

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Supplementary files

Article information


Submitted
27 Jul 2017
Accepted
13 Nov 2017
First published
16 Nov 2017

Nanoscale, 2017,9, 19279-19289
Article type
Paper

Plasmon-mediated cancer phototherapy: the combined effect of thermal and photodynamic processes

L. Ricciardi, L. Sancey, G. Palermo, R. Termine, A. De Luca, E. I. Szerb, I. Aiello, M. Ghedini, G. Strangi and M. La Deda, Nanoscale, 2017, 9, 19279 DOI: 10.1039/C7NR05522F

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