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Issue 32, 2017
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T1-Enhanced MRI-visible nanoclusters for imaging-guided drug delivery

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Abstract

Iron oxide nanoparticles with extremely low dimensions have recently been explored as positive (T1) contrast agent for magnetic resonance imaging (MRI). However, their small sizes lead to fast renal clearance and limit their use in elongated in vivo tracking or therapy monitoring. In this paper, we present a state of art approach to forming nanoclusters by crosslinking ultrasmall iron oxide nanoparticles with bovine serum albumin. This novel design not only maintains the T1 performance of the ultrasmall nanoparticles, but also significantly increases their blood circulation times from 15 minutes to over two hours. Our breast tumor model study also exhibited enhanced contrast at tumor sites for more than 24 hours. The ability of maintaining the T1 performance of the ultrasmall nanoparticles is significant, because previous studies have shown complete T1 loss or signal decrease upon polymer encapsulation. This design also shows great potential in encapsulating model drug molecules, which will greatly benefit the field of imaging-guided drug delivery.

Graphical abstract: T 1-Enhanced MRI-visible nanoclusters for imaging-guided drug delivery

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Article information


Submitted
12 Jun 2017
Accepted
28 Jul 2017
First published
28 Jul 2017

Nanoscale, 2017,9, 11785-11792
Article type
Paper

T 1-Enhanced MRI-visible nanoclusters for imaging-guided drug delivery

J. Sherwood, M. Rich, K. Lovas, J. Warram, M. S. Bolding and Y. Bao, Nanoscale, 2017, 9, 11785
DOI: 10.1039/C7NR04181K

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