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Issue 13, 2017
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AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging

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Abstract

Multi-modal imaging agents are desirable for tumor diagnosis because they can provide more information on the tumor than single-modal imaging agents. However, most reported multi-modal imaging agents are dual-modal agents rather than tri-modal agents; therefore, detailed information on the tumor may still be insufficient when such imaging agents are used. To ameliorate this issue, we synthesized a tri-modal imaging agent, composed of gold cluster and gadolinium oxide integrated nanoparticles (denoted as AuGds) using bovine serum albumin (BSA) as the template via a bio-mineralization method. The AuGds exhibit red fluorescence at ∼660 nm for optical imaging, strong X-ray absorption (around 700 HU) for CT imaging, and a high r1 value (∼12.39 mM−1 s−1) for MR imaging. After being chemically modified with folic acid (FA), the AuGds can specifically target folate receptors on KB tumor cells, and permit in vivo optical, MR, and CT imaging of xenografted tumors. By comparing these three imaging modalities, very clear structural and anatomical information on the in vivo tumor can be obtained. The AuGds show good biocompatibility, quick renal clearance, and do not induce normal tissue toxicity in vivo.

Graphical abstract: AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging

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Article information


Submitted
13 Feb 2017
Accepted
06 Mar 2017
First published
10 Mar 2017

Nanoscale, 2017,9, 4620-4628
Article type
Paper

AuGd integrated nanoprobes for optical/MRI/CT triple-modal in vivo tumor imaging

C. Xu, Y. Wang, C. Zhang, Y. Jia, Y. Luo and X. Gao, Nanoscale, 2017, 9, 4620
DOI: 10.1039/C7NR01064H

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