Issue 4, 2017
From the journal:

Nanoscale

Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents†

X. Luo,a   B. Li,a   X. Zhang,a   W. Zhao,a   A. Bratasz,b   B. Deng,c   D. W. McCombc  and  Y. Dong ORCID logo *a  

* Corresponding authors

a Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
E-mail: dong.525@osu.edu

b Small Animal Imaging Center, The Ohio State University, Columbus, Ohio 43210, USA

c Center for Electron Microscopy and Analysis, Department of Materials Science and Engineering, The Ohio State University, Columbus, Ohio 43210, USA

Abstract

Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agents in order to express functional proteins and provide real-time visualization. TT3-Gd18 LLNs were identified as a lead formulation, which was able to encapsulate 91% of mRNA and 74% of Gd. This formulation showed a comparable or a slightly higher delivery efficiency of mRNA compared to the initial TT3 LLNs. Moreover, a strong MRI signal was observed in the cell pellets treated with TT3-Gd18 LLNs. More importantly, TT3-Gd18 LLNs demonstrated an efficient delivery of mRNA and Gd contrast agents in vivo.

Graphical abstract: Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents

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Article information

DOI
https://doi.org/10.1039/C6NR08496F
Article type
Paper
Submitted
30 Oct 2016
Accepted
13 Dec 2016
First published
15 Dec 2016

Nanoscale, 2017,9, 1575-1579

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Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents

X. Luo, B. Li, X. Zhang, W. Zhao, A. Bratasz, B. Deng, D. W. McComb and Y. Dong, Nanoscale, 2017, 9, 1575 DOI: 10.1039/C6NR08496F

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