Jump to main content
Jump to site search

Issue 4, 2017
Previous Article Next Article

Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger

Author affiliations

Abstract

Nanocages (NCs) have emerged as a new class of drug-carriers, with a wide range of possibilities in multi-modality medical treatments and theranostics. Nanocages can overcome such limitations as high toxicity caused by anti-cancer chemotherapy or by the nanocarrier itself, due to their unique characteristics. These properties consist of: (1) a high loading-capacity (spacious interior); (2) a porous structure (analogous to openings between the bars of the cage); (3) enabling smart release (a key to unlock the cage); and (4) a low likelihood of unfavorable immune responses (the outside of the cage is safe). In this review, we cover different classes of NC structures such as virus-like particles (VLPs), protein NCs, DNA NCs, supramolecular nanosystems, hybrid metal–organic NCs, gold NCs, carbon-based NCs and silica NCs. Moreover, NC-assisted drug delivery including modification methods, drug immobilization, active targeting, and stimulus-responsive release mechanisms are discussed, highlighting the advantages, disadvantages and challenges. Finally, translation of NCs into clinical applications, and an up-to-date assessment of the nanotoxicology considerations of NCs are presented.

Graphical abstract: Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger

Back to tab navigation

Publication details

The article was received on 15 Sep 2016, accepted on 06 Dec 2016 and first published on 07 Dec 2016


Article type: Review Article
DOI: 10.1039/C6NR07315H
Citation: Nanoscale, 2017,9, 1356-1392
  •   Request permissions

    Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger

    P. Sahandi Zangabad, M. Karimi, F. Mehdizadeh, H. Malekzad, A. Ghasemi, S. Bahrami, H. Zare, M. Moghoofei, A. Hekmatmanesh and M. R. Hamblin, Nanoscale, 2017, 9, 1356
    DOI: 10.1039/C6NR07315H

Search articles by author

Spotlight

Advertisements