Issue 46, 2016
From the journal:

Nanoscale

Sprayable peptide-modified silver nanoparticles as a barrier against bacterial colonization†

Sarah McLaughlin,a   Manuel Ahumada,a   Walfre Franco,b   Thien-Fah Mah,c   Richard Seymour,a   Erik J. Suuronen*a  and  Emilio I. Alarcon*ac  

* Corresponding authors

a Division of Cardiac Surgery Research, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
E-mail: esuuronen@ottawaheart.ca, ealarcon@ottawaheart.ca

b Wellman Centre for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

c Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada

Abstract

Sprayable formulations of AgNPs were prepared by exchanging citrate capping agents with LL37-SH peptides. The AgNP@LL37 material was then combined with type I collagen to form a stable film once sprayed. The AgNP@LL37 spray prevented Pseudomonas aeruginosa (P. aeruginosa) proliferation and eradicated a P. aeruginosa biofilm, while being non-toxic for human skin fibroblasts embedded within 3D artificial skin constructs. Finally, no silver infiltration was observed after spraying on a full-thickness skin wound in a mouse model.

Graphical abstract: Sprayable peptide-modified silver nanoparticles as a barrier against bacterial colonization

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6NR07976H
Article type
Communication
Submitted
11 Oct 2016
Accepted
28 Oct 2016
First published
31 Oct 2016

Nanoscale, 2016,8, 19200-19203

Permissions

Request permissions

Sprayable peptide-modified silver nanoparticles as a barrier against bacterial colonization

S. McLaughlin, M. Ahumada, W. Franco, T. Mah, R. Seymour, E. J. Suuronen and E. I. Alarcon, Nanoscale, 2016, 8, 19200 DOI: 10.1039/C6NR07976H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements