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Issue 27, 2016
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High near-infrared absorbing Cu5FeS4 nanoparticles for dual-modal imaging and photothermal therapy

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Abstract

Multifunctional nanomaterials have shown excellent and promising properties for cancer diagnosis and treatment. Herein, we have developed iron doped copper sulfide (Cu5FeS4) nanoparticles with a non-covalent polyethylene glycol (PEG) coating (Cu5FeS4-PEG) for tumor dual-modal imaging and photothermal therapy (PTT). The obtained Cu5FeS4-PEG nanoparticles with high near-infrared absorbance could be used for phototoacoustic (PA) imaging and PTT, whereas Fe3+ doping offer the nanoparticles the additional property for magnetic resonance (MR) imaging. As shown by PA imaging, Cu5FeS4-PEG exhibit a high tumor uptake (āˆ¼10% ID gāˆ’1) after intravenous injection. In vitro and in vivo cancer treatment further confirm that Cu5FeS4-PEG could act as a novel therapeutic agent for PTT of cancer cells. Our study further promotes the potential applications of multifunctional nanomaterials in a range of tumor diagnoses and treatments.

Graphical abstract: High near-infrared absorbing Cu5FeS4 nanoparticles for dual-modal imaging and photothermal therapy

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Supplementary files

Article information


Submitted
02 Jun 2016
Accepted
07 Jun 2016
First published
08 Jun 2016

Nanoscale, 2016,8, 13368-13376
Article type
Paper

High near-infrared absorbing Cu5FeS4 nanoparticles for dual-modal imaging and photothermal therapy

Q. Zhao, X. Yi, M. Li, X. Zhong, Q. Shi and K. Yang, Nanoscale, 2016, 8, 13368
DOI: 10.1039/C6NR04444A

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