Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 8, 2016

Point of care testing of phospholipase A2 group IIA for serological diagnosis of rheumatoid arthritis

Author affiliations

Abstract

Secretory phospholipase A2 group IIA (sPLA2-IIA) was examined as a point of care marker for determining disease activity in rheumatoid (RA) and psoriatic (PsA) arthritis. Serum concentration and activity of sPLA2-IIA were measured using in-house antibodies and a novel point of care lateral flow device assay in patients diagnosed with varying severities of RA (n = 30) and PsA (n = 25) and found to correlate strongly with C-reactive protein (CRP). Levels of all markers were elevated in patients with active RA over those with inactive RA as well as both active and inactive PsA, indicating that sPLA2-IIA can be used as an analogue to CRP for RA diagnosis at point of care.

Graphical abstract: Point of care testing of phospholipase A2 group IIA for serological diagnosis of rheumatoid arthritis

Supplementary files

Article information


Submitted
27 Nov 2015
Accepted
25 Jan 2016
First published
01 Feb 2016

Nanoscale, 2016,8, 4482-4485
Article type
Communication

Point of care testing of phospholipase A2 group IIA for serological diagnosis of rheumatoid arthritis

N. J. Liu, R. Chapman, Y. Lin, J. Mmesi, A. Bentham, M. Tyreman, S. Abraham and M. M. Stevens, Nanoscale, 2016, 8, 4482 DOI: 10.1039/C5NR08423G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements